![]() ![]() ![]() The 25th compound he synthesized, in 1938, was lysergic acid diethylamide (in German, lyserg-saure-diathylamid), or LSD-25. Hofmann devised a technique to make a series of derivatives of lysergic acid called amides and began systematically looking for medically useful compounds. In the early 1930s, American researchers had identified the primary active ingredient of ergot, a chemical called lysergic acid. Twenty years earlier, researchers had isolated ergotamine, the first ergot alkaloid isolated in pure form, and the compound had become widely used for halting bleeding after childbirth and as a treatment for migraine headaches. Although ergot is poisonous, midwives had used a crude extract for centuries to induce labor in women. ![]() Hofmann was a talented synthetic chemist working in the Basel research center of Sandoz Laboratories - now Novartis - in the 1930s when he began studying the chemistry of ergot, the common name for a fungus that grows on rye, barley and certain other plants. ![]()
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